Write fascinating material and write every day.
Have more than one area. The more websites you have, the more ads have the potential
to get clicked.
Set up paths and observe your statistics across all sites. If one area is performing
poorly, consider changing the contents or the ad layout. Experimentation!
Change the ad layout and notification which layout toils best available for you. There are
many different layout options and there's no way you can know going in which
one will perform the best.
If you're blogging, writingup.com has a roster of profitable topics. They state that
you don't have to write on those topics but you might give it a try or at least plug
some of them in to the search engines.
Google different key words and phrases and note how much and what kinds of content and ads you see.
Don't be afraid to ask questions.